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Quantitative result bias due to matrix effect and tryptic efficiency was corrected through the use of synthetic isotope-labeled standards.
Percent relative standard deviation (% RSD) for matrix effect and matrix match effects were not more than 10%, for both bisphenols.
The method validation intends to investigate specificity, sensitivity, linearity, precision, accuracy, recovery, matrix effect and stability according to USFDA guideline.
Accuracy was assessed using recovery values ranging from 95.28% to 103.86%, which proves that this method does not suffer from a matrix effect and can be satisfactorily applied.
The results demonstrate the absence of a urine matrix effect and this is the consequence of the SPE process carried out.
The use of solid-phase microextraction technique avoided matrix effect and allowed to quantify the analytes in river water samples by using Milli-Q based calibration graphs.
Similar(36)
The applicability to natural samples was investigated through the study of matrix effects and toxin recovery.
Accuracy, precision, cross-reactivity, matrix effects and inter-operator variability were assessed.
This strategy allowed us to overcome matrix effects and to exploit second-order advantage.
The method was validated in terms of linearity, limits of detection (LOD) and quantification (LO Q, accuracy (trueness and precision), matrix effects, and robustness.
Chemistry and instrument design play a major role in some matrix effects and recommendations are given to minimise these or make them easier to correct.
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CEO of Professional Science Editing for Scientists @ prosciediting.com