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Bitar, M. et al. Effect of cell density on osteoblastic differentiation and matrix degradation of biomimetic dense collagen scaffolds.
The present study demonstrates the usefulness of sequence-based genome mining for potential drug targets representing one possible route for the prevention of matrix degradation of the mucosal epithelium by H. pylori and other pathogens.
Matrix degradation of the cells was measured by the release of [H]-collagen in the medium.
These results indicate that MSU-stimulated OBs may be directly implicated in matrix degradation of bone with MSU deposits.
A main source of GAGs in GCF is derived from extracellular matrix degradation of periodontal tissues during the progression of periodontal disease.
These events occur mainly at the intraluminal thrombus circulating blood interface, and pathological mediators are conveyed outwards, where they promote matrix degradation of the arterial wall.
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Histology of control humeri revealed two fronts of hypertrophic chondrocytes, with matrix degradation indicative of bone deposition at the mid-diaphysis (Fig. 7).
Previously, we have described the development of an inhibitory antibody, Fsn0503 [15], and now demonstrate its mode of action through inhibition of matrix degradation and invasion of endothelial cells resulting in the inhibition of tube formation in vitro.
Because of their known involvement in cartilage matrix degradation, production of MMPs in the cultured explants was analyzed.
This finding was important because it links senescence with matrix degradation, one of the major problems in disc degeneration.
The PPP allows nonoxidative glucose degradation and enables a lactate-based matrix-degradation of the surrounding tissue (Stern et al, 2002).
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