Sentence examples for matrix contraction by from inspiring English sources

Our findings are relevant for understanding the role of matrix contraction by cells during wound healing and cancer development, and may provide design parameters for materials to guide morphogenesis in tissue engineering.

As expected, mevalonate restored both matrix contraction by CAFs and their ability to generate matrix permissive for SCC12 invasion.

All these results indicated that TSP1 is induced during PDGF-mediated and TGFβ-mediated matrix contraction by normal fibroblasts.

In this report we investigate whether activation of latent TGFβ by TSP1 plays a key role in matrix contraction by normal and scleroderma fibroblasts.

Figure 7A shows that depletion of integrin α5 reduces matrix contraction by CAFs (efficacy of siRNAs #1 and 2 shown in Figure 6A).

Further analysis showed a positive correlation between matrix contraction by CAFs and their ability to promote SCC invasion (Supplementary Figure 1).

Matrix contraction is blocked by a ROCK inhibitor, Y27632, which reduces actomyosin contraction.

We wanted to evaluate whether TSP1 mediates matrix contraction in fibroblasts by assessing if interfering with binding of TSP1 to TGFβ suppresses the basal and TGFβ-induced contractile activity of normal or SSc fibroblasts.

To exploit the biological significance of the interacting networks in the enriched pathways, we compared the topological informational scores of the integrin family with the percentage of matrix contraction due to knockdown of integrins by siRNA in stromal fibroblasts (Table 4).

This led us to speculate that compounds that block matrix contraction would also block carcinoma cell invasion promoted by CAFs.

The effect of Batimastat on collagen matrix contraction was analyzed with a linear mixed model fit by restricted maximum likelihood.