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Because adherent cell growth and differentiation are regulated by cell-cell and cell extracellular matrix contacts, we hypothesized that this advantage is a result of the unique cell adhesion pattern formed by their multiple cell layers and abundant extracellular matrix.
The relative distance between closest and farthest membrane/substratum separations are consistent with reported distance between focal and matrix contacts.
Indeed, in non-polarized MDCK cells, both PtdIns(4,5 P2 and PtdIns 3,4,5 P3 colocalize at cell-cell and cell-extracellular matrix contacts.
Overall, these findings reflect the widespread importance of signal transduction, transcriptional regulation, and cell:extracellular matrix contacts in growth and morphogenesis of the developing face.
During EMT epithelial cells break down cell-cell and cell-extracellular matrix contacts and migrate to other locations in the body [27].
Consequently, cells lose relevant properties, such as differentiation, polarization, cell-cell communication and extracellular matrix contacts, while wound healing, inflammatory processes, and hyper-proliferation are artificially promoted.
Similar(42)
The monomict megabreccias display both "block facies" and "matrix facies" architecture and show internal deformation at the block-matrix contacts.
Here, we show that different fibroblast-like and epithelial cell lines maintain normal proliferation rates and form functional cell-matrix contacts in DLW-fabricated 3D scaffolds of different mechanics and geometry.
Mechanical stress is transmitted from the GBM to the actin cytoskeleton of podocyte foot processes via cell-matrix contacts that contain mainly integrin α3β1 and a variety of linker, scaffolding, and signaling proteins, which are not well characterized in podocytes.
Furthermore, the molecular composition of cell-matrix contacts forming in these 3D micro-environments and under conventional 2D culture conditions is identical, based on the analysis of several marker proteins (paxillin, phospho-paxillin, phospho-focal adhesion kinase, vinculin, β1-integrin).
Podosomes represent a subgroup of cell-matrix contacts, which is especially prominent in cells of the monocytic lineage such as monocytes, macrophages and dendritic cells, but also in a variety of other cell types.
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