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Extracellular matrix composition can modulate stem cell fate and direct differentiation.
In each tissue and in different regions of the same tissue, matrix composition can vary.
The matrix composition can be readily adapted to specific neural cell types, notably by incorporating appropriate neurotrophic growth factors.
Thus, this report highlights that the cell microenvironment and subtle differences in matrix composition can play an important role on cell phenotype in vitro.
Local variations in the matrix composition can lead to inaccurate quantitative results because of alterations in material ablation, aerosol transport, and analyte ionization efficiencies.
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Changes in matrix composition and stiffness can be measured in vitro, in vivo and ex vivo.
This large variation of bone matrix elasticity at fixed mineral composition can be explained by introducing more finely defined ultra-structural features into the composite model.
It has been previously shown that Tbx genes can regulate extracellular matrix composition and cell adhesion [40], which are important factors in the bending of the heart tube [41].
In the first analyses, we used only one substitution matrix (hence one equilibrium GC content) for the whole gene while base composition can be highly heterogeneous along genes, which could have been problematic.
Both these techniques have drawbacks and results can be difficult to compare for samples with different matrix composition.
These findings can be explained by differences found in the resin matrix composition.
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