Significance: The alterations of matrix composition produced by dedifferentiated chondrocytes may limit the mechanical stability of neocartilage constructs.
Primarily, the causes of OA are aging, obesity, mechanical stress [ 1], oxidative stress [ 2] and altered nutrient levels [ 3], all of which have been found to affect matrix composition, presumably by modulating rates of macromolecular biosynthesis and degradation.
We hypothesized that complex changes in cartilage matrix composition are reflected by changes in chondral optical properties in the NIR region.
The matrix composition affects analyte ionization by correlation of the theoretical offset and even more by the correlation of the responsivity slope in the measurement of the calibration curve.
Tensile and impact properties of the blends are hardly influenced by matrix composition and chain architecture, but predominantly vary with the amount of rubber.
The scaffold provided by the ECM seems to hold a 'memory function', as studies using decellularized lungs showed cell fate to be significantly influenced by matrix composition, thereby indicating long-term implications of ECM remodeling with respect to pulmonary repair capacity and aging related processes [6,32].
The central role that the primary cell wall plays in regulating extension growth, cell adhesion and cell morphology, requires a tight temporal-spatial regulation of its rheological properties, which are ultimately determined by matrix composition and structure.
It is not clear whether such changes in matrix composition of xenografts are caused by the tumor cells, or by changes in mouse stroma[ 14].
In addition, a rheological study was successfully carried out on extruded composites to reduce cost by altering the matrix composition.
Isolation had the main independent contribution to explaining the probability of occurrence, followed by landscape matrix composition and patch size.
