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Renal fibrosis results from an imbalance between synthesis and degradation of extracellular matrix components, with enhanced production of types I and III collagens and fibronectin [40].
Consistent with these results, analyses of the aged rat prostate [37], [38] as well as global studies using different tissues and species including mice and humans [50], identified greater expression of inflammatory and stress-response genes, along with a decrease in extracellular matrix components with age [50], [51], [52].
The FACIT collagen IX is directly and indirectly involved in the mutual interaction of the extrafibrillar matrix components with cartilage fibrils [ 76].
In addition, we have identified non-coding RNA genes and differentially expressed transcript isoforms of known matrix components with ageing which require further investigation.
Conjunctival specimens of the control and latanoprost group revealed a loose arrangement of extracellular matrix components with a moderate collagen density and enlarged empty spaces.
The proposed model suggests that type I collagen is a crucial component of a regulatory loop that links protease breakdown of extracellular matrix components with vascular permeability.
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Impressive results have also been obtained with complex mixtures of extracellular matrix components, notably with liver-derived "biomatrix" (Enat et al., 1984; Wang et al., 2011) or with Matrigel, a biomatrix preparation derived from the Engelbreth-Holm-Swarm (EHS) sarcoma (Orkin et al., 1977).
This is in agreement with the IAR degradation of fibrous extracellular matrix components and with the loss of the oligosaccharide fraction which in turn impacts on the ability of tissue to retain bound water [ 27, 32].
Rauch, U. Extracellular matrix components associated with remodeling processes in brain.
To see if the extracellular matrix components compete with LipL32 for the binding site of PLG or interfere somehow in the interaction with PLG, the binding assay was performed in the presence of increasing concentrations of collagen type IV or plasma fibronectin.
DSPP encodes for a large precursor protein that is cleaved into dentin sialoprotein (DSP) and dentin phosphoprotein (DPP), two prominent extracellular matrix components involved with dentin mineralization.
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