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The influence of sample matrix components on the sensor response was studied according to Plackett Burman experimental design.
Additionally, the influence of sample matrix components on the electrode response was studied according to the Plackett Burman experimental design.
Most recent studies focus on the NP-induced (negative) effects on enzymatic functions, but scarce reports of the potential impact of incubation matrix components on NPs have been published.
The elucidation of the pathway fluxes differentially upregulated or downregulated in the presence of ECM based hepatocyte cultures will provide a methodology to identify the effect of matrix components on hepatocellular metabolism for augmented function.
This further demonstrated the suppressive effect of the matrix components on the signal intensity.
Decrease in the sensitivity is attributed to the influence of matrix components on the antibody binding in the solution and/or on the chip surface.
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The cellular and extracellular matrix components of vessels, with specific emphasis on the regulation of collagen type I, have implications in vascular spatial organization.
Structure matrix, components of the matrix.
It is possible that these two analytes compete with matrix components for active sites on the SPE cartridges.
Antoniou et al [ 17] have used different enzymes to examine the effect of degradation of individual matrix components (for example, collagen or proteoglycans) on magnetic resonance imaging parameters.
Although the detailed mechanisms of the "cellular crosstalk" that controls the angiogenic activation of endothelial cells induced by the coculture are still under investigation, it seems that the coculture with primary osteoblasts provides on the one hand proangiogenic matrix components and on the other hand angiogenic growth factors to promote angiogenic activation of OECs [ 20, 32].
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