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He concluded that the matrix changes were caused by the adaptation of the patellar tendon to the ACL environment.
Twelve ovarian tumor cell lines were plated onto pre-stained N3F-derived matrices while cell-induced matrix changes were recorded and analyzed over time.
OA subchondral bone matrix changes were detected by Raman spectroscopy.
Albeit based on a limited number of cartilage samples, the present study suggests that OA matrix changes were disease-related rather than age-related.
The matrix changes were highly comparable between GOLD stages, with collagen content in the alveolar wall increasing further in GOLD IV.
Interestingly, extracellular matrix changes were observed in OC-affected horses, often associated with a disruption of cartilage canals [ 33, 44– 44].
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Another interesting way of viewing telluric distortion matrix changes is by mapping Mohr circles at specific periods for each site in the array.
Therefore overall the matrix changes are consistent with the degenerate tendon attempting to heal, with a progressively mechanically weak scar tissue being laid down as part of this failing remodelling process.
We consider that such matrix changes are important in the development of the ossified plaque, particularly in the fused and tuberous subtypes of OLF, compared with the lateral, extended, and enlarged subtypes [ 19].
Bladder Smooth Muscle Cells (BSMCs) undergo phenotypic changes such as hyper-proliferation, de-differentiation and altered expression of integrins and ECM proteins.[ 1] Extracellular matrix changes are often crucial inciting events for fibroproliferative disease.[ 2] Epigenetic change, specifically DNA methylation, may be important factors underlying the persistent fibroproliferative phenotype.
Furthermore, using partially digested collagen networks, we explored how osteoarthritis-relevant degradation alters the aggrecan collagen molecular interactions, which in turn, affects cartilage tissue properties at the early stages of OA, when OA-induced matrix changes are indistinguishable via either macroscopic or microscopic analyses.
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