Considering the presence of CD44 ligand hyaluronan, which enhanced cell aggregation, and the presence of E-cadherin, which mediated cell-cell interaction, we presented a model of cell-matrix-cell interaction based on the observation of the two groups of cell mixture (Figure 6B).
Studies with animal tissue suggest that cell-cell and extracellular matrix-cell interactions are important in the retention of Type II cell morphology in vitro.
They are distributed in virtually all cell types and involved in various cell-cell and matrix-cell interactions ranging from differentiation to signal transduction [ 82, 83].
Their functions include various types of cell-cell and matrix-cell interactions and they have been implied in forming membrane microdomain structures and thereby working as "molecular facilitators" [ 82] or "molecular organizers" [ 81].
In vivo, stem cells are thought to reside in a so-called stem cell niche, where their properties are carefully regulated by the structural and functional conditions of the extracellular matrix, cell-cell interactions, and complex signaling cascades [ 23].
The stem cell is a complex microenvironment combining an extracellular matrix, cell-to-cell interactions, and other factors such as growth factors, physical factors, and various cytokines.
This lectin regulates cell-cell and cell-extracellular matrix interactions, cell signaling, inflammatory responses and biological events, such as cellular activation, migration, differentiation, apoptosis and tumor metastasis [15].
Epsin 3 (EPN3) is involved in extracellular matrix-epithelial cells interactions [82].
Certainly, changes in cell-matrix interaction can switch the functional outcome of the cell [50], [51].
Komatsu, M., Carraway, C., Fregien, N. L. & Carraway, K. L. Reversible disruption of cell-matrix and cell-cell interactions by overexpression of sialomucin complex.
