Sentence examples for matrix assembly in from inspiring English sources
Agarose overlay of insulin activated keratocytes in culture is a useful model for studying corneal stromal extracellular matrix assembly in vitro.
The Drosophila eggshell provides an in vivo model system for extracellular matrix assembly, in which programmed gene expression, cell migrations, extracellular protein trafficking, proteolytic processing, and cross-linking are all required to generate a multi-layered and regionally complex architecture.
Engineering fibronectin matrix mimetics that bypass the need for cell-dependent fibronectin matrix assembly in chronic wounds is a novel approach to stimulating cellular activities critical for tissue repair.
Similarly, knockdown of endogenous R-Ras decreased fibronectin matrix assembly in FLNa expressing cells (Fig. 5E).
These results indicate that FLNa enhances the ability of R-Ras to promote fibronectin matrix assembly in melanoma cells.
Here, we explore the interplay between α5 integrin expression, sFN concentration, and Fn matrix assembly in cellular aggregates whose cohesion is predominantly mediated by integrin-Fn interaction.
Interestingly, several research groups reported that increased expression of genes involved in extracellular matrix assembly and in regulating the cytoskeleton correlated with higher metastatic capacity (Bittner et al, 2000; Clark et al, 2000; Winnepenninckx et al, 2006).
Accordingly, it was not possible to perform 3D invasion assays in the presence of the fragment in order to determine whether blocking matrix assembly results in rescue of the invasive phenotype.
Moreover, integrin activation and fibronectin matrix assembly increased in melanoma cells expressing active R-Ras and full length FLNa.
The extracellular matrix is composed of different proteins: decorin and lumican are members of the small leucine-rich proteoglycan family of proteins and are involved in matrix assembly and structure, and in the control of cell proliferation [ 6].
A 70 kDa amino-terminal FN fragment (100 µg/ml; Sigma) was used to inhibit FN matrix assembly [41] as in [33].
