Sentence examples for matrix assembly by from inspiring English sources
Surprisingly, and contrary to previous studies with juvenile bovine cells, matrix assembly by adult human MSCs was dramatically hindered compared to donor-matched FCs cultured similarly.
Together, the results of this study suggest that the process of extracellular matrix assembly by chondrocytes on three-dimensional scaffolds may be independent of in vivo conditions experienced by the tissue prior to harvest.
The experiments presented herein suggest that breast cancer cell-secreted factors deregulate early Fn matrix assembly by stromal cells.
As decorin functions to regulate matrix assembly by modulating collagen spacing and organization, GZMB likely contributes to the loss of adventitial collagen architecture through the cleavage of decorin.
In addition, the effect of low oxygen tension, which has previously been shown to enhance matrix assembly by chondrocytes, was investigated.
This implies that the subcellular deposition, rather than the relative levels of PrPC expression, correlates with the corresponding prion conversion rates and may be due to a decrease in ECM proteolysis upon Fn1 downregulation ((Axel et al, 2001) and this study) and/or a disruption of FN matrix assembly by undersulphated HSPGs (Galante & Schwarzbauer, 2007).
As discussed earlier, the individual FN domains including 70-kDa can also inhibit FN-matrix assembly by interfering with fibril formation by the full-length molecules.
Low levels of vitronectin (VN) have been shown to enhance FN-matrix assembly by increasing the expression of matrix-assembly sites on the cell surface [ 136, 226].
FN fragments and modules can also inhibit FN-matrix assembly by competing for FN-assembly sites [ 187], which could act as a feedback system to regulate FN levels on the cell surface.
In an interesting study, which demonstrated the essential role of FNIIIA+FN in lymphatic-valve development,α9β1 integrin was shown to be required for the assembly of EIIIA+FN by lymphatic endothelial cells [ 80]; however, this assembly mechanism may be isoform-specific, as a separate study found that overall FN-matrix assembly by EIIIA-FN null fibroblasts was unaffected [ 119].
We analyzed the hypothesis that expression of nonmuscle myosin (NMM -II isoforms iNMM -II isoformsmotinvolvedechanosensing, and extracellular motilityssemechanosensinged by the 3 fandors in human trophoblast (HTR8/SVnextracellularvitro and in the matrixplassemblyn vivo.
