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Next, hierarchical clustering was performed, where the distance matrix between drugs was measured using the Jaccard Distance Matrix as implemented in the R package vegan [76].
The algorithm was used in conjunction with the population Fisher information matrix as implemented in MATLAB (PFIM 1.1 and 1.2) to evaluate population pharmacokinetic designs.
The advantage of the Literature Matrix as implemented in the Web suite is its availability over the web to the whole outcomes research community.
Phylogenetic analyses were conducted using Neighbor-joining methods and the Jones–Taylor Thornton (JTT [ 75]) substitution matrix, as implemented in PAUP* b1.0 [ 76].
The protein sequence alignment was conducted with the L-INS-i algorithm under the JTT-200 substitution matrix, as implemented in Mafft version 6 [ 47].
Therefore, we included a scaled Euclidian distance matrix to the cross-correlation matrix as implemented in FSL (Tomassini et al. 2007).
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Pair wise identities by state (IBS) were calculated for all 966 samples based on autosomal SNPs using identity matrices as implemented in the GenABEL library [46].
We assessed whether geographic variation in morph frequencies in C. decresii can be explained by genetic and/or environmental factors using multiple matrix regression as implemented in FSTAT ver. 2.9.3.2 [ 46].
Amplified fragment length polymorphism results were displayed with principal co-ordinates analyses, computed on a Jaccard distance matrix between individuals, as implemented in the 'vegan' R CRAN package.
Putative transcription factor binding sites (TFBS) were scanned within 2 kb upstream and downstream of the annotated transcriptional start site utilizing a position-weight matrix (PWM) scan as implemented in cureos package v0.3 ([ 45]; http://www.bepress.com/sagmb/vol2/iss1/art7) and described in Westermann et al. [ 46] for R open-source software http://www.R-project.org.org
The algorithm implementation makes use of a computing environment that uses the parallel distributed computing message passing interface (MPI) and specialized vector-matrix class representations, as implemented in the third-party software package, OOPS.
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