The PCEN regions consist of a nonrepetitive region (core) and regions containing repetitive elements, as identified by dot matrix analysis.
We compiled the transcripts from KIIs and organized the information based on the 4 domains and 16 sub-domains as identified in the matrix.
As such, cell hypertrophy and proliferation as well as matrix expansion were identified as few of the common biological responses of mesangial cell to injury.
Functional categorization as identified using Gene/Gene Set overlap matrix with 17 TFs identified as biomarkers for full set of OC genes (additional file 8) showed overlap which were prominent for cell cycle associated TFs based on data from E2F1, E2F3-4 and TFDP-1 genes.
The concatenated matrices were partitioned following the optimal partitioning strategy as identified in PartitionFinder.
Particle debonding in combination with subsequent plastic void growth and shear yielding of the matrix are identified as major energy dissipating mechanisms in all three regimes of FCP.
The large components of a deviating eigenvector computed from the Pearson correlation matrix are identified as gene members that belong to a specific functional module involved in a similar cellular pathway.
For pathway core gene set, matrix [6,2,1,8,7,1,8] was identified as the optimal matrix.
The higher amounts of matrix PGs identified in scoliotic tissue as well as the differences in fine chemical composition of their GAG chains may reflect the modified architecture and functional failure of scoliotic tissue.
Table 1 Confusion matrix Identified as affected Identified as unaffected Affected nodes True positive (TP) False positive (FP) Unaffected nodes False negative (FN) True negative (TN).
