Sentence examples for matrix and ultimately from inspiring English sources

The consequent loss of sulphated glycosaminoglycans, which are intrinsic components of the aggrecan molecule, compromises both the functional and structural integrity of the cartilage matrix and ultimately renders the tissue incapable of resisting the compressive loads applied during joint articulation.

The types of scaffold used to enable cells to function in an appropriate manner to produce the required extracellular matrix and ultimately a tissue of a desired geometry, size and composition are considered here.

Liver fibrosis is a significant health problem which represents the liver's scarring process and response to injury through deposition of collagen and extracellular matrix, and ultimately leads to cirrhosis.

In migraineurs, a reduction in mitochondrial energy would favour a metabolic shift directing tyrosine metabolism toward decarboxylation pathway instead of the hydroxylation one, leading to reduced catecholamines production and high trace amine levels in the pain matrix, and, ultimately, to the trigemino-vascular system activation, triggering the attack [1].

The periodical CO2-renewing sorption process was applied in the solid state foaming of poly ethylene terephthalate) (PET), in order to decrease the sorption time, increase the concentration of CO2 in PET matrix, and ultimately increase the expansion ratio of PET foams.

Loss of intervertebral disc (IVD) matrix and ultimately disc height as a result of 'degeneration' has been implicated as a major cause of low back pain (LBP).

A future challenge will be to determine whether the BoNT-encoding plasmids play a role in the development and/or flexibility of C. botulinum, thus potentially increasing its adaptability to certain niches, such as specific environments and food matrixes, and ultimately contributing to the disease of botulism.

The algorithms' performance is subsequently evaluated and compared by averaged confusion matrices and ultimately by boxplots of misclassification rates.

It hardly heals spontaneously and its alterations often lead to further extracellular matrix degradation and ultimately, to the loss of joint function.

Proteoglycans bind at specific sites along the fibrils [6,7] and play a role in fibril assembly, matrix organisation and ultimately corneal transparency [8].

VEGF, upregulated by hypertrophic chondrocytes, may in turn induce the invasion of blood vessels to cartilage, secretion of MMPs, extracellular matrix remodeling, and, ultimately, cell death [ 55].