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Conversely, collagen matrix and tissue stiffness were not affected by inhibition of cell-generated contraction forces.
Emphasis is placed on those factors that contribute to bone strength; geometry, architecture, mineralization, the nature of the organic matrix and tissue heterogeneity.
In lung fibrosis tissue architecture and function is severely hampered by myofibroblasts due to excessive deposition of extracellular matrix and tissue contraction.
Subsequently, the patterned cells were transferred to extracellular matrix and tissue at which point they changed their morphologies and formed tubular structures.
Through the interaction of heparan sulfate (HS) with both activating FGF polypeptides and transmembrane FGF receptor (FGFR) tyrosine kinases, the system is rigorously modulated by the extracellular matrix and tissue architecture.
Mathematical analysis showed that the dorsal ventral difference in the amount of HSPG is not sufficient to generate the observed difference in pattern, indicating that both extracellular matrix and tissue architecture play a role in this system.
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As a result, recapitulation of in vivo properties (i.e., cell expansion, homing, and interaction with matrix and tissues) might be impacted by biased interactions between human and murine molecules, leading to erroneous interpretations.
With the expanding application of magnetic nanoparticles in cellular culture-matrix and tissue engineering, the interaction between nanomaterials and cells is becoming a central issue [1, 2].
S100A4 may mediate invasive potential by regulating matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases such as TIMP2 [31].
HA is an important component of connective tissue matrices where its functions include promoting matrix assembly and tissue hydration and viscosity of some fluids, and modulating cell-cell or cell-matrix interactions [ 1].
Matrix metalloproteinases are zinc-dependent endopeptidases involved in matrix degradation and tissue remodeling [ 43].
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