Taken together, these results indicated that culture within a floating/compliant collagen matrix promotes alveologenesis and luminal differentiation of basal HMECs.
In summary, this suggests that apical secretion and luminal matrix assembly are common strategies for tubular organ expansion in Drosophila.
We find that COPI vesicle transport is required to: a) secrete of multiple luminal proteins, b) assemble a luminal matrix and c) expand the diameter of tubular organs.
As their expression patterns correlate with that of apical and luminal matrices detected by antisera and lectins that detect the typical mucin-type O-glycosylations [7], these proteins may represent new components of such matrices.
In this work we demonstrate that the two genetically identified factors haunted and ghost are essential for polarity maintenance, membrane topology as well as for secretion of the tracheal luminal matrix and the cuticle.
The metabolite formation was strongly affected also by the presence of the fruit or beverage matrix, suggesting that the isolation of PAs from the matrix causes luminal interactions with enzymes and proteins, but consumption of PA-rich fruits and beverages does not.
Atherosclerosis occurs through a slowly progressing lesion formation and luminal narrowing of arteries whereby lipids, inflammatory cells, and extracellular matrix accumulation in the subendothelial space (intima) lead to plaque formation.
Atherosclerosis commences with the deposition of lipoprotein particles into the subendothelial matrix and the recruitment of monocytes to the luminal surface of the endothelium.
These molecular subtypes include: basal cell-like, Her-2/neu, luminal A, and luminal B.
Note GB wall thickening and luminal sludge indicating acute cholecystitis.
