Our results suggest that this effect is likely mediated by an interaction with the factors of the extracellular matrix and enhancement of cancer cell motility.
OSM stimulation of cells induces diverse functions across a variety of tissue types and cell lines such as modulation of growth and differentiation, inflammation, remodeling of extracellular matrix, and enhancement of metastatic capacity [ 11- 14], however the exact role that this cytokine plays in bone biology has not yet been clearly defined [ 10, 15].
Enhanced mineralized matrix deposition and enhancement of osteoblastic signal expression in response to culture in these systems have been widely reported.
The results indicate that this effect is most likely mediated by the interaction of KLK6 with factors of the extracellular matrix and the enhancement of cancer cell motility by KLK10.
However, the decorrelating detector suffers from two drawbacks: (1) Its relatively high computational complexity which is of the order of O(N 3) [1], where N in the dimension of the system's cross-correlation matrix and (2) noise enhancement effect.
They are also major contributors to VEGF and TGF- β production in the peritoneum, providing more stimuli for extracellular matrix (ECM) production (fibrosis) and enhancement of the local vascular networks [ 6], leading to angiogenesis, a third consequence of PD.
Ideally, the peak area, while related to the concentration in homogeneous samples, needs to be adjusted using an element specific calibration constant and a matrix specific correcting term which accounts for the matrix effects such as absorption and enhancement.
The 2D AOA estimator proposed in [15] uses two-parallel ULAs, whereas the method in [16] is based upon matrix enhancement and the matrix pencil algorithm.
In addition to the synthesis of nonchondrocytic ECM and enhancement in matrix degradation, chronic inflammation also induces cell death.
Furthermore, matrix effects were estimated as the signal suppression and enhancement (SSE) ratio to determine whether the use of matrix-assisted calibration curves in the experiments was necessary.
Metastasis is a phenomenon composed of multiple sequential cascades and various cyto-physiologic changes, including reduction of tumor cell adhesion, degradation of extracellular matrix (ECM), enhancement of cell motility, and promotion of neo-vascularization [ 4].
