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If the fiber to matrix adhesion is poor, a composite may fail at the interface, reducing in particular the tensile strength.
Cr VI) treated and transformed cells were more sensitive to trypsinization, suggesting extracellular matrix adhesion is a major target of Cr VI).
Matrix adhesion is essential for cell attachment.
This implies that all five fiber types support cell proliferation at a similar rate and that the difference in matrix adhesion is attributed to the difference in initial cell density on various matrices.
Reduced extracellular matrix adhesion is a potent terminal differentiation stimulus for cultured keratinocytes [ 47], and this raises the possibility that Notch ligand-specific effects on adhesion could explain why Dll1 differs from Jagged1 in its effects on differentiation [ 16 ].
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The genes associated with cell to matrix adhesion were significantly down-regulated in Cr VI) transformed cells, including many genes involved in focal adhesion.
In renal carcinoma ACHN cells, similar inhibitory effects of EG3287 on matrix adhesion were observed.
A tendency to reduced matrix adhesion was also reported in immortalized endothelial cells obtained from lungs of HIF-2α knockout mice [ 36].
The fiber-matrix adhesion is evaluated through environmental scanning electron microscopy studies.
Paxillin, an important protein for cell-matrix adhesion, is also down-regulated by Hakai overexpression; however, Hakai-dependent paxillin down-regulation is proteasome-independent (Rodríguez-Rigueiro et al., 2011).
However, α6β4-mediated cell-matrix adhesion is critical in normal keratinocyte attachment, signaling and anchorage to the basement membrane through its interaction with laminin-5, raising potential risks for targeted therapy.
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