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For all matrices used the fold occurrences of the c-Myc binding sites of the analyzed promoters in total are increased in comparison to the fold occurrences of the c-Myc binding sites of the control gene promoters in total.

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We parameterize the gain matrices using the LMI conditions.

Next, we developed three-dimensional (3D) peptide-HA matrices using the A99/AG73 mixture.

Resulting matrices were compared with FlyReg matrices using the Kullback-Leiber distance [17].

The results varied for the different matrices using the three different cones.

We generated position weight matrices using the sequences from the top ten enriched motifs.

Principal Component Analysis was performed on these matrices using the prcomp function.

Neighbor-joining trees were generated based on distance matrices using the Jones-Taylor-Thornton model.

Trees were built from these matrices using the Phylip Neighbor-Grouping software, with default settings [ 65].

Triplicate aliquots of the supernatants were used to determine the HA concentrations within the matrices using the ELISA kit.

We reconstruct the phylogenomic trees from the distance matrices using the Neighbor-joining method as implemented in the PHYLIP package.

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