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Referee 1: Nicolas Galtier CNRS-Université Montpellier II Montpellier, France This manuscript implements a very good idea, namely injecting population genetic parameters, typically used to model microevolution, in substitution matrices, typically used to model long-term sequence evolution.
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A confusion matrix is typically used for evaluating the performance of a predictive algorithm (Fielding and Bell 1997).
We compared our scoring matrices with the typically used BLOSUM62 scoring matrix with ours scaled to the same level of divergence (62% expected sequence identity).
The operators are n-by-n complex matrices, which are typically used to describe internal degrees of freedom such as spin.
The thermoset matrices that are typically used in structural composites are generally well known for extreme brittleness, sensitivity to defects, and poor performance at complex strain states.
The latter application is particularly interesting because some lasing chromophores show enhanced emission in DNA compared to the typically used synthetic polymer matrices.
Finally, we conducted a review of the literature to determine the sample sizes typically used when parameterizing matrix models used to study plant demography.
Finally, what range of sample sizes is typically used to parameterize matrix models of plant demography, and how do these sample sizes compare with those at which bias in estimates of λ becomes negligible?
Mercury is excreted in breast milk, but it is not typically used as a matrix for assessing exposure, primarily because of low concentrations and variability in the proportion present as MeHg (Björnberg et al. 2005; García-Esquinas et al. 2011; Miklavcic et al. 2011).
The accuracy of effective medium approximations that are typically used in the mixed matrix membrane literature to predict the overall permeability is assessed through comparison with the exact numerical results, and alternative homogenization processes and simplified expressions are suggested.
Fluorescently-labeled cues are typically used to observe biochemical patterns in hydrogel-based matrices with a high degree of resolution; however, this approach requires additional expense and time for peptide labeling and fluorescence imaging.
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