Enhancement of the macroscopic plasticity of the AACs was mainly attributed to the strain relaxation in the β phase and to the formation of multiple shear bands in the amorphous matrix triggered by the deformation-induced phase transformation inside β, knowledge of which greatly deepens understanding of the complex micromechanical behaviors in advanced AACs.
In summary, we show here that mitochondria exhibit spontaneous elevations in their matrix pH triggered by bursts of depolarization that both propagate faster than matrix GFP along connected mitochondria.
Arsenic mobilization from the silty matrix was triggered by abrupt changes in redox conditions and displays a clear relationship with the temporal dynamics of the oxidation/reduction potential.
Overall, these data demonstrated that the alteration of the extracellular matrix may be triggered by alveolar overdistension.
Successful design of a pH responsive polyelectrolyte-based virus delivery matrix with extracellular release triggered by tumor acidosis has been achieved.
Tissue remodeling is triggered by matrix-metalloproteinases (MMPs) and the vascular endothelial growth factor (VEGF), which were found differentially expressed in patients with endometriosis [ 41, 42].
Frequently, this occurs between tumor cells such as breast, cervical, or colon carcinoma cells and can be triggered by matrix detachment (Overholtzer et al., 2007), suggesting that loss of integrin-mediated adhesion may promote cell-in-cell invasion.
Entosis is defined as the homotypic invasion of tumor or epithelial cells into their neighboring cells, triggered by extracellular matrix detachment.
Expansion of adipose tissue is associated with a remodeling of the extracellular matrix (ECM) and angiogenesis [4], events triggered by the production, by adipocytes, of ECM proteins and remodeling proteases such as members of the matrix metalloproteinase (MMPs), their inhibitors (TIMPs) [5] [7], or cathepsins [8], [9] and the production of angiogenic factors such as VEGF or leptin [10] [12].
Our data suggests that while both early and later matrices sustain mesenchymal invasion of MDA-MB-231 cells, only late stromal 3D matrices support a change of invasive strategy triggered by beta1-integrin inhibition.
