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Synthetic matrices should mimic some aspects of the natural properties of the collagen scaffold and adjacent proteins of the extracellular matrix (ECM), which constitutes a highly hydrated and fibrous network that supports cell attachment, migration, and other functions.
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Ideal scaffolds for tissue engineering should mimic natural extracellular matrix (ECM) as much as possible.
An ideal cardiac patch should mimic the native extracellular matrix environment for cardiac cell support and provide the necessary framework for cell signaling molecules or growth factors.
Ideally, these biomaterials should mimic the function of the extracellular matrix (ECM) which not only provides mechanical support for cells, but also supplies signals that direct cell attachment, proliferation, differentiation and metabolism [7,8].
The ideal scaffold should mimic the naturally occurring environment in the articular cartilage extracellular matrix (ECM), allowing chondrocyte proliferation and synthesis of cartilage ECM, which is composed by a dense network of collagen fibers [ 7], proteoglycans (PGs), and other proteins [ 8].
The simulant should mimic actual lunar regolith, and the distribution of its mechanical properties should vary along the longitudinal direction.
In this regard, the control group should mimic usual prescribing habits as best as possible [30 33].
Realistic: The environment used for testing should mimic the actual network deployments as closely as possible.
The bio-compatible dental implant should mimic the micro-motion of the natural tooth.
Therefore, a tissue engineering scaffold should mimic native ECM to recreate the in vivo environment.
The light box should mimic being outside in sunlight.
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