For example, the elements of a binary data matrix may represent the mutation status at a set of genomic positions (rows) in a collection of genomes (columns).
Together, this study represents a comprehensive laboratory and field evaluation of currently available sample stabilization matrices that may represent viable alternatives to dried blood spots.
Interventional studies targeting fibrosis in CAN have previously been directed at modifying the synthesis or the breakdown of matrix proteins [ 13], inhibition of matrix protein cross-linking, and thereby matrix deposition, may represent a viable alternative.
Her investigations are focused on the pathophysiology of major psychoses, testing the hypothesis that extracellular matrix abnormalities may represent a core feature of the pathology of these disorders.
The existence of dual effects for TGF-βs in tumor progression follows the observation that TGF-β-induced growth inhibitory responses and extracellular matrix responses may represent distinct processes in certain cell types.
Fiber-reinforced cementitious matrix (FRCM) composites may represent a valid alternative to the use of traditional techniques for strengthening and retrofitting existing reinforced concrete (RC) and masonry structures.
Thus, we suspect that matrix-bound VEGF may represent a more responsive signaling modality than free VEGF, at least to the presence of proteases.
Growing evidence suggests that abnormal extracellular matrix (ECM) remodeling may represent a common pathway for cyst formation and development in ADPKD and ARPKD kidneys.
Our results suggest that MEK/ERK and Egr1 are required for TNFα-regulated catabolic and anabolic genes of the cartilage extracellular matrix, and hence may represent potential targets for drug intervention in osteoarthritis or rheumatoid arthritis.
However, we have obtained preliminary results with G. sulfurreducens cluster 5 knockout mutants, which indicate that this β group cluster regulates the expression of extracellular matrix material, and may represent a new way that chemotaxis-like signaling pathways can participate in biofilm formation (HT Tran, DR Lovley and RM Weis, unpublished observations).
