The integration of Bi (1.6 times the atomic volume of As) in the GaAs matrix may cause an increase in the substitutional energy because of the strain, reducing the solubility of the As atoms and allowing the gathering of the Bi ones.
Microangiopathy with impaired angiogenesis and excessive accumulation of extracellular matrix may cause severe hypoxia in SSc [ 53, 54].
The tunnels formed in matrix may cause diffusion of drug molecules outside and accelerate hydrolysis by allowing easier water absorption inside [ 33].
A balance between the presence of PG and the rigid collagen network plays a key role in normal cartilage, and insufficient viscoelasticity resulting from low GAG content in the cartilage matrix may cause collagen loss.
The Jacobian matrix of the LM formulation can be derived from the Jacobian of the PL formulation by assuming k → ∞, as (A.11) J λ = A B B ^ 0, where the 0 block matrix results in a non-positive definite Jacobian matrix which may cause numerical difficulties.
It should be kept in mind, however, that the peptide enrichment procedure in combination with the different characteristics of serum and urine samples may for a substantial part determine whether or not Hep-1 and/or Hep-2 are isolated, implicating that changes in this procedure or altering matrix compositions may cause changes in their relative detection.
Thus, whereas matrix degradation due to fluctuating temperatures is the likely cause for increased filler particles exposure after thermocycling, citric acid may cause matrix degradation by the same effects.
Barri et al. reported that sodium and potassium formate may cause matrix effects and interferences affecting co-eluting polar metabolites [ 71].
For LC MS applications the cations in the anticoagulants are still a subject of debate, in particular which added cations may cause matrix effects.
Recent research, however, has shown that the recovery of exogenous vitamin D metabolites differs between immune and chromatographic assays and that the use of non-human serum may cause matrix effects [ 58, 60] and is therefore inappropriate when comparing results derived from different methods.
