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We synthesized a novel porous scaffold, a collagen sponge incorporating a hydroxyapatite/chondroitinsulfate composite (pCol-HAp/ChS), containing materials which resemble extracellular matrices in bone and cartilage tissues, which needs high compressive strength for clinical use.
These polymeric materials (PLA, PGA and PLGA) have been used as temporary extracellular matrices in bone tissue-engineering scaffolds [ 64] as well as sutures, thereby providing evidence of safety [ 27].
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Acidic SCPP or SIBLING genes are involved in the ossification of collagenous matrix in bone and dentine, and P/Q-rich SCPP genes are involved in the production of enamel, milk, tears and saliva.
Briefly, I study the interaction between cells and the extracellular matrix in bone.
Osteopontin (OPN) is an important component of the extracellular matrix in bone.
This also correlates with the histological findings of an absence of collagen (the main component of the organic matrix in bone and dentin) in highly mineralized areas.
It was generally considered that ordered proliferation and differentiation of osteoblast was indispensable for mineralization of extracellular matrix in bone formation during wound healing [ 6].
The alteration of the organic matrix in bone by advanced glycation end products could be relevant to increased bone fragility with aging and in such disease as diabetes (19, 20).
The organic matrix in bone consists of approximately 90% type I collagen, while the remaining 10% is composed of proteoglycans and numerous non-collagenous proteins, of which osteocalcin and osteonectin constitute 40%to50%0% [ 22, 23].
As the specific ingredients of type I collagen, which is known as the most common protein in the skeleton, comprise about 90% of the organic matrix in bone tissue, ICTP is the degradation product of mature bone matrix but not of newly formed bone.
Biosynthetic responses to physical energy (ultrasound, electromagnetic fields) observed in vitro and in vivo increase in DNA synthesis, cell proliferation, extracellular matrix in bone and connective cells— Hsu and Chang (2004) have suggested the possibility of clinical use of this energy in bone and connective tissue repair.
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