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Plackett and Burman, 1946 designs and Hadamard matrices have traditionally been studied for this purpose.
Hadamard matrices have traditionally been used for screening main effects only, because of their complex aliasing structures.
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Although MMPs have traditionally been thought to cleave extracellular matrix components and so disrupt extracellular matrix contacts with the tumour and potentiate tumour cell spread and metastasis, other biological roles for MMPs in cancer are now known [20], [53].
Advances in tissue engineering have traditionally led to the design of scaffold- or matrix-based culture systems that better reflect the biological, physical and biochemical environment of the natural extracellular matrix.
Economists have traditionally had a smaller toolkit.
Everywhere castes have traditionally been endogamous.
Charities have traditionally been conservative marketers.
Wildcats have traditionally caused problems for unions.
The British have traditionally been less enthusiastic.
Agrarian societies have traditionally consumed little meat.
Incompatibilists have traditionally said "No".
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