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This chapter focuses on design criteria for FDA-approvable and affordable matrices for cell delivery.
Here we mimic spider silk – Nature's high performance material – for the design of chemically defined 2D and 3D matrices for cell culture.
We investigated whether blending the hydrophobic PCL with poly (glycerol sebacate) (PGS) or chitosan (CHI) improves the biocompatibility of the matrices for cell expansion.
Hydrogels are widely used as matrices for cell growth due to the their tuneable chemical and physical properties, which mimic the extracellular matrix of natural tissue.
Chitosan collagen composite materials have potential as matrices for cell encapsulation and delivery, or as in situ gel-forming materials for tissue repair.
Several marine biomaterials are currently being proposed for the sustained delivery of bioactive compounds, often triggered by external stimuli, which may be combined with polymeric matrices for cell culture, on the development of the so-called functional biopolymers.
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Bioactive hydrogels formed from the Michael-type addition reactions of end-functionalized poly (ethylene glycol) macromers with thiol-containing protease-sensitive peptide crosslinkers have previously been described as matrices for cell-induced enzymatic remodeling.
// Set the convergence matrix for cell ii.
DeQuach, J. A., Yuan, S. H., Goldstein, L. S. & Christman, K. L. Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds.
This porous film is shown to be suitable as a matrix for cell growth.
The scaffold should act as a temporary matrix for cell proliferation and extracellular matrix deposition, with subsequent tissue ingrowth.
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