Our results revealed that tumor-conditioned Fn matrices were stiffer and more unfolded than control matrices, and that these dysregulated matrices contributed to enhanced VEGF secretion by stromal cells.
A slightly lower score of 90% is achieved when considering only the network data without GDV similarity matrices, indicating that graphlet similarity matrices contribute to capturing relations, which would otherwise be missed.
Plasmin is a broad-substrate protease involved in a number of (patho physiological processes, of which fibrinolysis and damage of extracellular matrices contribute to bacterial dissemination within the host [ 12, 27, 28].
We find that the endoderm secretes a type IX collagen, Col9-a1, that is deposited onto the basal epidermal matrix, contributing to activation of Ddr on the ventral surface of the migrating TVCs, thus promoting integrin-based cell-matrix adhesion.
Alongside this function, it has been suggested that halomucin might establish the framework of a cross-linked extracellular matrix contributing to the rigidity and maintenance of H walsbyi's unique square cell morphology [6].
MMP-2 and MMP-9 degrade type I and IV collagen and breakdown the extracellular matrix, contributing to cancer metastasis.
Lactate efflux, besides contributing to the glycolytic flux for energy and anabolic intermediate production, also detains an important role in the extracellular matrix, contributing to cancer malignancy [ 13].
