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Overall, this study indicates that highly porous anisotropic jet-sprayed matrices are interesting candidates for valve tissue engineering, through anisotropic mechanical properties, efficient cell population, conservation of stem cells phenotype and recovery of hVIC physiological phenotype.
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[Editors' note: further revisions were requested prior to acceptance, as described below.] The data regarding the sensitivity of endogenous TGFβ to stiffness of the matrix are interesting and important for the study.
The manuscript has been improved but there are some remaining issues that need to be addressed before acceptance, as outlined below: The data regarding the sensitivity of endogenous TGFβ to stiffness of the matrix are interesting and important for the study.
For both the masculine and the feminine scores, the matrix difference in terms of the strength of associations favoring the milk matrix is interesting and will be discussed later.
The results are interesting.
Focal adhesions are interesting protein complexes since they serve to both transduce mechanical signals and mechanically link the actin cytoskeleton to the extracellular matrix.
The ability to prepare Polydiacetylenes based materials in the polyvinylidene fluoride matrix polymer is interesting due to the combination of colorimetric and electrical signaling.
After the lukewarm notices for "The Hulk" and "The Matrix," it has been interesting to note the praise heaped on "Terminator 3: Rise of the Machines," for its refreshing (and relative) lack of pretension.
The authors point out that the idea is not that all these (often hundreds or thousands) SAR matrices are inspected visually, but that interesting elements in the matrices can be identified automatically, for instance "virtual compounds" (core-substituent combinations not yet made) that are predicted to have interesting activity.
Among the most interesting possible host matrices are mesoporous silica and hybrids (organo-silicates) in the form of powders (MCM-41 like) and transparent bulk or film xerogels.
This property becomes interesting when kernel matrices are considered under analogy to covariance matrices of Gaussian distributions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com