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All aligned matrices and phylogenetic trees are deposited in Treebase (accession S10740).
Distance matrices and phylogenetic analyses were conducted using MEGA 4.0.
Our approach is flexible and robust enough to model several variants of the motif finding problem, including those incorporating substitution matrices and phylogenetic distances.
Distance matrices and phylogenetic trees were reconstructed from the exact evolutionary relationships between elements (no further stochasticity is introduced to mimic the accumulation of mutations).
Data matrices and phylogenetic trees have been deposited in the Dryad Data Repository (http://doi.org/10.5061/dryad.gr93t; Mandel et al., 2014).
Similarly, BindML [ 12] uses local MSAs, specialized substitution matrices, and phylogenetic tree construction to obtain the likelihood that a given patch MSA belongs to a PPIS (described below).
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AFLP presence/absence matrix and phylogenetic analyses are deposited in treeBASE under study 14798 (http://purl.org/phylo/treebase/phylows/study/TB2 S14798).
The SNP matrix and phylogenetic trees are available at TreeBase.org, study number S14912.
Character Matrix and phylogenetic tree have been deposited in treebase (ID: 16569) and data are available at the following URL: http://purl.org/phylo/treebase/phylows/study/TB2 S16569.
Homology matrix and phylogenetic trees were constructed using Neighbor-Joining method (Bioedit) and TreeTop-Phylogenetic Tree Prediction (GeneBee-Molecular Biology Server available at http://www.genebee.msu.su).msu.su
Sequence alignments (nucleic acid and amino acid) were constructed using ClustalW 1.74 (16 ) and refined by visual inspection with SEAVIEW; distance matrix and phylogenetic trees were computed with PHYLO_WIN (17 ).
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