Here, we used flow cytometry to analyze the time-dependent behavior of antigen-specific effector (Teff) and regulatory (Treg) T cells and microglia in mice model of MS, Experimental Autoimmune Encephalomyelitis (EAE), and compared the observations with a mathematical cross-regulation model of T-cell dynamics in autoimmune disease.
In order to analyze the influence of B-cell depletion on the dynamics of T-cell subpopulations, we performed a sensitivity analysis of our mathematical cross-regulation model with the aim of identifying the model parameters governing the dynamics induced by this therapy in T cells.
But the commission would never switch over to a purely mathematical basis for regulation, he said, especially in areas where it has less experience, like the digital control systems that have replaced some analog controls in 30-year-old reactors, it would use engineering judgments to demand an appropriate level of backups, what it calls called "defense in depth".
Using a mathematical description of regulation of gene expression (Equation 1) and a procedure for computation of its parameters from experimental data, it was possible to construct a complete numerical model of the genetic network of yeast cyclins active during cell cycle.
To gain greater understanding of this we developed a mathematical model of regulation of the Nrf2 system and tested its predictions.
In the context of genetic regulation, the mathematical models are usually strongly nonlinear, involving sigmoidal regulation functions.
Our mathematical model uncovers key regulations that can be manipulated to enhance sporulation efficiency, an important first step in the development of new strategies for producing gametes with high quality and quantity.
In this work, we have developed a mathematical model for the regulation of the global regulators KorA and KorB of RK2 plasmids, a natural example of an autogenous, negatively self-regulated transcriptional system.
One of the major hindrances in building detailed mathematical models for genetic regulation is the large number of unknown model parameters.
We here review selected mathematical models of feedback regulation of fluid transport at the cell scale and identify a general "core shell" structure of such models.
A mathematical model for the regulation of juvenile hormone titers.
