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Oceanographers first calibrated the colour of the ocean in CZCS photographs with measures of primary productivity such as that developed by Steeman-Nielsen, and then used the colour measurements to obtain better mathematical estimates of phytoplankton productivity than were previously available.
Data provided by the Chronic Kidney Disease Epidemiology Collaboration have shown that mathematical estimates of GFR can result in up to about 20%% discordance in drug-dosing recommendations, depending on the formula used [32].
Our results demonstrate that in critically ill patients exhibiting ARC, mathematical estimates of GFR are insensitive in identifying this phenomenon.
Mathematical estimates of GFR and creatinine clearance are flawed in the critically ill, and will tend to significantly under-estimate renal function in those with ARC.
The mathematical estimates of GFR chosen for comparison included: Cockcroft-Gault (CG), modified CG, 4-variable and 6-variable MDRD formulae (Table 1).
Although various mathematical estimates of glomerular filtration are widely applied [ 19, 20], each was primarily designed for use outside of the ICU, making application in this setting flawed [ 21, 22] and of little value in guiding therapy.
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Alain Goriely developed mathematical estimates to predict the effects of swelling on axonal stretch.
Because of the many approximations needed to obtain a closed form mathematical estimate for the variance of the protein level, we also ran computer simulations for the dependence on variance on the promoter strength and other parameters.
Mathematical estimates suggest most of the common SNPs to have originated thousands of years ago and therefore to have a wider geographic distribution in contrast to rare variants which are mostly more recent and geographically restricted [ 25].
Clinicians should be cautious in altering prescriptions on the basis of mathematical estimates alone.
Cherry et al. have also examined measured CLCR versus mathematical estimates in a cohort of critically ill and traumatised patients.
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