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Where no experimental data were available, mathematical estimates, either from computational reports or from our own estimations, were used in the models.
Data provided by the Chronic Kidney Disease Epidemiology Collaboration have shown that mathematical estimates of GFR can result in up to about 20%% discordance in drug-dosing recommendations, depending on the formula used [32].
Clinicians should be cautious in altering prescriptions on the basis of mathematical estimates alone.
Importantly, our data demonstrate that mathematical estimates have poor clinical utility in comparison to either measure.
Cherry et al. have also examined measured CLCR versus mathematical estimates in a cohort of critically ill and traumatised patients.
Our results demonstrate that in critically ill patients exhibiting ARC, mathematical estimates of GFR are insensitive in identifying this phenomenon.
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As demonstrated, each mathematical estimate was significantly lower than the median measured CLCR value.
Comparisons with each mathematical estimate are presented in Table 3 and Figure 3.
Because of the many approximations needed to obtain a closed form mathematical estimate for the variance of the protein level, we also ran computer simulations for the dependence on variance on the promoter strength and other parameters.
The second source of error in our calculation of food waste results from our mathematical model estimates of average food intake.
The developed mathematical relationship estimates edge-of-field peak concentrations of pesticides from aerobic soil metabolism half-life (AERO), organic carbon-normalized soil sorption coefficient (KOC), and application rate (RATE).
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