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JM: study conception, research design, mathematical analysis, manuscript writing.
SW: study conception, research design, mathematical analysis, manuscript writing.
In this context, kurtosis is defined positive and the kurtosis values can be directly compared: systems with higher kurtosis will have higher degree of specialization JM: study conception, research design, mathematical analysis, manuscript writing.
HY: study conception, research design, mathematical analysis, manuscript writing; BZ: model constructing, experimental study, manuscript writing; SL: directed the design of the model constructing, experimental study, study conception, helped with the bioinformatics analyses, participated the revision of the manuscript; QZ: formulated and directed the design of the study.
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EdeS, JS., CW. and MPHS designed the study; EdeS, TT., PJI, IA, JS and MPHS analyzed the data; CW and MPHS performed the mathematical analysis; the manuscript was written jointly by EdeS, JS, CW and MPHS.
Specific author contributions: Amnon Sonnenberg: conception and design, mathematical analysis, and writing of manuscript.
IV designed the study, helped with the mathematical analysis and wrote the manuscript.
ASK conceived and designed the study, performed mathematical analysis, and wrote the manuscript.
The following abbreviations are used: CDE – Clathrin dependent endocytosis, CIE – Clathrin independent endocytosis, EGF – Epidermal Growth Factor, EGFR – Epidermal Growth Factor Receptor, mono-Ub – mono-ubiquitination HSG designed the study, performed the simulations and mathematical analysis and wrote the manuscript.
BF developed the original BNS code, developed and evaluated the mathematical analysis tools and helped draft the manuscript.
JLM directed the mathematical analysis and participated in drafting the initial manuscript.
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