Sentence examples for maternal tolerance of from inspiring English sources

However, natural allogeneic tolerance can be equally robust, as is seen in maternal tolerance of the fetal paternal semi-allogeneic HLA.

Several mechanisms underlie this maternal tolerance of fetal tissues.

This phenomenon is often referred to as the Th1-Th2 shift of pregnancy and is thought to contribute to maternal tolerance of the fetus by suppressing the antifetal cell-mediated immune response.

It acts as an interface between the fetal and maternal blood circulation, ensuring (1) oxygen and nutrient transfer and waste removal, (2) immune protection and maternal tolerance of the semiallogeneic fetus, and (3) endocrine functions ([ 1, 2], for reviews).

Despite this, 60 years on there is still no experimental evidence to support the notion that systemic maternal tolerance of T cells is required for successful human pregnancy (Colucci et al., 2014), although elegant mouse experiments have provided evidence that lack of regulatory T cells does lead to fetal demise (Rowe et al., 2012; Samstein et al., 2012).

Studies in mouse models show that Treg cells are essential for maternal tolerance of the conceptus, and that expansion of the Treg cell pool through antigen-specific and antigen non-specific pathways allows their suppressive actions to be exerted in the critical peri-implantation phase of pregnancy.

Accordingly, failure of maternal tolerance to the fetus has been suggested as a mechanism of adverse pregnancy outcomes: recurrent pregnancy loss, fetal growth restriction, and preeclampsia [9] [11].

During normal pregnancy the dominant immune response is of Th2 origin and this helps to facilitate maternal tolerance for the fetus.

The embryo modulates this response inducing the expression of endometrial molecules that suppress the immune response and promote maternal tolerance to the embryo.

In the best spirit of maternal tolerance, Mother Bear indulges her little cub Bradley in his insatiable desire to play.

More recent studies have linked inflammation and a loss of maternal tolerance with PE.