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CONCLUSION: High VDRL titers at treatment and delivery, earlier maternal stage of syphilis, the interval from treatment to delivery, and delivery of an infant at ≤36 weeks' gestation are associated with the delivery of a congenitally infected neonate after adequate treatment for maternal syphilis.
After multiple imputations to account for missing data, maternal stage of disease and maternal syphilis emerged as additional risk factors.
Although more women having clinical AIDS in the pre-HAART cohort could have contributed to the worse prognosis of the infants, in multivariate analysis reduced mortality in infants born post-HAART remained significant even when adjusted for maternal stage of disease.
We detected transcripts corresponding to maternal (Stage 1) expression of hpse1 and lrig2, but not hpse2.
The temporal expression pattern of Rx3-regulated genes was further profiled during early development from maternal stage until visual function is fully mature.
Therefore polyadenylation is a key process in regulation of translation (for recent reviews see [ 43, 44]), and thus serves as an important step in post-transcriptional regulation in maternal stage embryos.
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Maternal stages are characterized by a rich abundance of mitochondrial transcripts.
It was observed an enrichment of 3'UTR isoforms in degrading and stable transcripts (abundant in the maternal stages) compared to activating ones (abundant in zygotic stage).
In order to be termed degrading, minimum 95% of the transcripts had to be located in maternal stages (oocyte until blastula).
In maternal stages (oocyte to blastula), mitochondrial genes encoded 45.9 50.6% of the transcripts, reflecting a high energy demand in embryos up until MZT.
This result suggests a more complex post-transcriptional regulation in the maternal stages since transcriptional regulation cannot be applied to control developmental processes prior to MZT.
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