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From this analysis I conclude that intronic maternal microRNAs are frequently produced from introns of maternally deposited gene transcripts.
Tang, F. et al. Maternal microRNAs are essential for mouse zygotic development.
First, some maternal microRNAs are highly expressed in the ovary.
This tell us that maternal microRNAs are already known in Drosophila.
Maternal microRNAs often are encoded within the intron of maternal genes, suggesting that many maternal microRNAs are the product of transcriptional hitchhiking.
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Their set of maternal microRNAs is virtually identical to the set here described.
Third, a large proportion of maternal microRNAs is also transcribed later on during development.
However, the characterization of maternal microRNAs is particularly difficult because they are too short for standard genetic analyses.
The evolutionary impact of maternal microRNAs was estimated by the use of comparative genomics and population genetics.
Recently, it has been shown that maternally transmitted microRNAs are adenylated during the maternal-to-zygotic transition (MZT) (Lee et al. 2014 .Whether maternal microRNAs have a functional impact in Drosophila eggs is still unknown.
Here we show that many of these microRNAs are found in maternal serum, at levels that increase with gestational age.
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