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Lack of oxygen to the brain, low birth weight due to multiple births after in vitro fertilization and maternal infection, including benign conditions like periodontal disease, have been linked to cerebral palsy.
An environmental risk factor that has been proposed for autism and other ASDs is maternal infection during pregnancy.
Maternal infection is associated with oxidative stress and inflammation.
Maternal infection is clinically identified in 30 to 40% of pregnancies complicated by preterm labor.
Decreasing the time from PROM to delivery is associated with lower rates of maternal infection.
Maternal infection or inflammation may induce fetal inflammatory responses and potentially fetal brain injury.
Maternal infection or inflammation may induce fetal inflammatory responses associated with fetal injury and cerebral palsy.
Rates of neonatal sepsis (at <10 days) and maternal infection were not statistically different.
CMV educational and hygienic measures have the potential to prevent primary maternal infection.
The reported intrauterine transmission rate of CMV following primary maternal infection is approximately 40%.
Maternal infection is a cause of adverse developmental outcomes including embryonic resorption, intrauterine fetal death, and preterm labor.
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