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The theme here is maternal immune dysregulation.
Maternal immune activation alters fetal brain development through interleukin-6.
Several studies have implicated maternal immune dysregulation during pregnancy in association with ASD.
A more 'activated' maternal immune system at admission was also associated with histologic chorioamnionitis.
Among its multiple effects, this hormone contributes to the suppression of maternal immune response to the conceptus32.
However, changes in the maternal immune system required to accommodate the allogeneic fetus may alter the immunogenicity of influenza vaccines.
The successful pregnancy depends on maternal immune tolerance against the fetus.
During pregnancy the maternal immune system has to adapt its response to accommodate the fetus.
The need for maternal immune recognition during mammalian pregnancy is still unclear.
But when the HLA molecules are a little too close for comfort, the maternal immune system apparently gets confused: which is real, and which the imposter?
"Left to its own, the maternal immune system would destroy the conceptus".
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