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Exact(5)
Thus, mice with a maternal deletion from Ube3a to Gabrb3 are molecularly more similar to the AS patients with a large maternal deletion of chromosome15q11 q13.
Thus the finding of an overall increase in USVs in pups with a maternal deletion from Ube3a to Gabrb3 was somewhat unexpected but not surprised.
Heterozygous females were bred to wild type C57BL/6J males to produce heterozygotes with a maternal deletion from Ube3a to Gabrb3 (m−/p+) and wild type littermates (m+/p+).
Thus, mutant mice with a maternal deletion from Ube3a to Gabrb3 provide an AS mouse model that is molecularly more similar to the contiguous gene deletion form of AS in humans than mice with Ube3a mutation alone.
Analyses of maternal (m−/p+), paternal (m+/p−), and homozygous (m−/p−) deletion mice indicate that mice with a maternal deletion from Ube3a to Gabrb3 provide an AS mouse model that is molecularly more similar to the common contiguous deletion form of AS, and thus valuable for future comparative studies.
Similar(55)
We conducted a battery of behavioral tests for mice with a maternal or paternal deletion from Ube3a to Gabrb3.
The frequency of seizure activity in Ube3a to Gabrb3 maternal deletion mice was not different from that of maternal Ube3a deficiency alone (21%) previously reported [23].
Ceroni et al. [15] identified a child with both ASD and asthma, who inherited a maternal deletion that resulted in a BST1-CD38 fusion transcript.
This may suggest a selective deficit in anxiety related behavior in maternal deletion mice.
Our extensive behavioral characterization of both maternal and paternal deletion mice supports that the maternal deletion mouse is a valid model for the contiguous gene deletion form of AS.
Mice at age 8 10 weeks with a maternal deletion (m−/p+), paternal deletion (m+/p−), and their wild type (m+/p+) littermates were used for the tests.
Related(20)
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