When examining the maternal genotype assignments following maximum likelihood analysis in Colony2 for colonies without a genotyped queen, queen genotypes were occasionally ambiguous (i.e., assigned a genotype with probability <0.9).
Lastly, information on address at conception was unavailable, and, therefore, we were limited to basing the exposure assignment on maternal address at delivery.
At regular time points during the study, the neurobehavioral status of the infants is assessed using either standardized examinations conducted by research team members who are 'blind' to the infants' group assignments or through maternal questionnaires (Table 2).
Finally, errors in the routine maternal and infant records and assignment of LTFU status may have constituted information bias.
EEM & AIA contributed with other authors in assignment of cause of maternal death from verbal autopsy data.
PR helped develop methods for dietary nitrate, nitrite, and nitrosamine assignment and provided input into maternal factors to be considered in analyses.
For maternal outcomes (Aim 2), research assistants blinded to the study group assignment will collect all data.
An assumption behind our exposure assignment, therefore, is that the concentrations at and near maternal residential locations were representative of exposures experienced during gestation.
That is, given a descent graph of a pedigree and an assignments of alleles a = (a1,…, a2 f ) to the maternal and paternal variables of its f founders, every maternal and paternal variable is assigned a specific founding allele.
It was also the most significant determinant in the final model for waist-height ratio, a marker of central adiposity, overall neonatal adiposity as determined by SS + TR and sum of skinfolds, independent of maternal BMI, neonatal gender, total gestational age, maternal education or study group assignment.
