Finally, we collected data from the Causes of Death Register (for a data linkage outline, see Online Supplementary Material under "Supplemental data" in the online issue).
With the HC diet, participants were advised to consume additional portions of bread, potatoes, and rice to compensate for the energy reduction that resulted from decreased fat intake (see Online Supplemental Material under "Supplemental data" in the online issue for details of the advice).
Serum osmolality was significantly positively correlated with serum Na+ (r = 0.73, P < 0.001), urea (r = 0.47, P < 0.001), creatinine (r = 0.30, P < 0.001), and glucose (r = 0.36, P < 0.001) but not with serum potassium (see Supplementary Table 2, online supplementary material under "Supplemental data" in the online issue.
Additional details of how the summary results from the FACIT trial were incorporated are provided in the Supplementary Material: Methods Appendix (under "Supplemental data" in the online issue).
In this study, the within-village correlations were relatively low for all outcomes of interest (ranging from 0.02 to 0.07; see Supplementary Material Table 1 under "Supplemental data" in the online issue).
Although post hoc power calculations did not provide additional information to that already present in the CIs, we, nevertheless, verified that the sample was adequate to confirm effect sizes of 0.2 0.3 (see Supplementary Material Table 1 under "Supplemental data" in the online issue) by using the observed SEs and intracluster correlations actually observed.
The data from the 94 breast cancer case and control subjects for these tables is publicly available at under Supplemental Materials to Publication.
See online supplemental material and Supplemental Table 1 under "Supplemental data" in the online issue for a definition of lipoprotein subclasses and complete list of metabolites quantified, respectively.
Supplemental Materials and Methods Supplemental Figures and Legends.
A CONSORT flow diagram (Supplemental Figure 1 under "Supplemental data" in the online issue), along with precise details of this protocol and the rationale for our approach/methods (Supplemental Figures 2 and 3 under "Supplemental data" in the online issue), are provided as online supplementary materials with this article.
