Excluding fellow eyes with CNV, accumulations of depolarizing material in outer retinal layers appeared in 11 eyes (69%) and remained stable in 8 eyes (50%) until month 24.
Accumulations of depolarizing material in outer retinal layers increased in 1 of these eyes from months 12 24; 2 eyes showed a decrease from baseline through month 24.
Ectopic depolarizing material in outer retinal layers changed from 26 affected eyes (26/31, 84%) at baseline to 19 eyes (19/31, 61%) at month 12 and 16 eyes (16/31, 52%) at month 24.
The origin of accumulations of depolarizing material in outer retinal layers is unclear, possibly representing exudative components such as previously described lipid exudates containing melanin from RPE-derived macrophages, migrating into outer retinal layers owing to reactive metabolic activity induced by the neovascular process.
The decreasing amounts of ectopic depolarizing material in outer retinal layers found in our study may also indicate a dynamic response of the RPE following anti-VEGF therapy supported by earlier findings of intraretinal RPE migration in AMD using SD OCT, published by Ho and associates.
Furthermore, the migration of malignant cells from the vitreous to the retina, as demonstrated by Chan et al., may explain the appearance of the hyperreflective material in the outer neuroretinal layers before accumulation in the sub-RPE space.
In this regard, the feasibility of using a commercial grade ferroboron alloy as potential alternate shielding material in the outer subassemblies of future Indian fast reactors has been recently investigated from shielding physics point of view.
Planet formation should proceed more slowly at relatively greater distances from the host star, according to this idea, because orbital speeds are reduced and there is less raw material in the outer reaches of the disk.
So how much material wealth is floating in outer space?
Intensity-based SD OCT B-scans were compared to polarization-sensitive OCT images regarding RPE integrity and correlations of hyperreflective material with depolarizing foci in outer retinal layers.
