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In this review, we summarize the commonly applied conductive materials for scaffold construction and evaluate their contributions in the regeneration of electro-active tissues.
Several groups have reported use of metals, ceramics, synthetic polymers and composites, and silk fibroin as potential materials for scaffold fabrication in BTE.
The tissue engineering materials for scaffold should be biocompatible, biodegradable, and mechanically stable, which depends on the material's chemistry, solubility, structure, shape, hydrophobicity/hydrophilicity, surface energy, water absorption, molecular weight.
For this reason, synthetic CaP materials including HAp are FDA-approved and were among the most investigated materials for scaffold composition for over three decades [ 46– 51].
Polymers are the raw materials for scaffold production in tissue engineering, and several types of biodegradable polymers are utilized in the development of artificial skin, surgical sutures, vascular grafts, bone joining devices, and controlled-release pharmaceuticals [ 32].
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Controlled biodegradability as well as swelling behavior, superior bioactivity and improved mechanical properties of the PVA/doped ZrP nanocomposite films make them promising matrix materials for scaffold-guided tissue engineering application.
Concerning the creation of new materials for scaffolds and bone substitutes, one requirement is the hydroxyapatite growth on the surface by exposing to body fluids, which can also be observed on oxidized porous silicon, which is more stable in simulated body fluids than pure porous silicon [7].
Porcine small intestinal submucosa, while once promising, has been exposed as a poor material for scaffold development.
Silk fibroin (SF) has been reported as a suitable material for scaffold fabrication for tissue engineering application owing to its remarkable mechanical and biocompatible properties [5].
The materials used for scaffold fabrication not only determine the physical properties of biocompatibility, biodegradability, and mechanical stability, but also provide appropriate signals for directing the cellular processes that induce tissue formation [ 60, 62].
To improve cell seeding efficiency and cytocompatibility, we designed a new coating material for scaffolds.
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