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Decellularized extracellular matrix (ECM) derived from tissues and organs are emerging as important scaffold materials for regenerative medicine.
The design of materials for regenerative medicine has focused on delivery of small molecule drugs, proteins, and cells to help accelerate healing.
Understanding how stem cells integrate biomaterials properties through focal adhesions during differentiation is important for the design of soft materials for regenerative medicine.
The present work may provide additional insight into the mechanisms by which the physical microenvironment influences cell fate decisions, and has specific application to the design of new materials for regenerative medicine applications with adult stem cells.
Human pluripotent stem cells, such as embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), have the ability to differentiate into various cell types, and will become a potential source of cellular materials for regenerative medicine.
Human iPS cells (hiPSCs) have attracted considerable attention for applications to drug screening and analyses of disease mechanisms, and even as next generation materials for regenerative medicine.
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Fibrin is an attractive material for regenerative medicine applications.
The implants were decontaminated with etching gel, and the defects were filled with autologous bone mixed with an osteoinductive material for regenerative treatment of bone defects.
However, few studies have focused on human oral mucosa fibroblasts (hOFs) as material for regenerative medicine, and little is known about the molecular basis of their characteristics.
In addition, these cells provide an unlimited source of 'raw material' for regenerative medicine therapies of many incurable diseases, including diabetes and heart disease.
Collagen is an attractive material for regenerative medicine applications as it is biocompatible, lowly immunogenic, can be remodelled by cells and is already used in numerous clinical applications (reviewed in [22]).
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