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Protein dose and release kinetics affected material resorption rates and the progression of the regeneration process.
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Moreover, a material's resorption rate should match the formation rate of the new bone tissue [ 29].
Gerlachfilled 44 mandibular cysts with Ostim® and reported complete material resorption with an extemely low complication rate[ 65].
Hyaluronan (HA) can be chemically modified to engineer robust materials with pre-selected mechanical properties and resorption rates that can be dictated by the intended clinical use.
Resorption rates of transplanted bone graft material in the alveolar bone widths and heights were (ABB 29.7 ± 8.8%, HA+rhBMP-2 31.5 ± 7.4%) and (ABB 39.2 ± 21.8%, HA+rhBMP-2 52.6 ± 6.5%), respectively.
Despite these advantages, these ceramic materials are associated with high brittleness and slow resorption rates compared to glass microspheres.
Though a vast amount of research has been done on calcium phosphate ceramic microspheres for dental and orthopaedic applications [highlighted in the recent review by Bohner et al. (2013)] there still remain some issues related to these ceramic materials such as high cost, time-consuming lengthy or complicated manufacturing processes, brittleness and slow resorption rates.
Also, Marc Bohner has indicated that the mechanism of material resorption may be different [1].
This procedure may be associated with high complication, re-operation, and resorption rates [70].
However, ceramic-based microspheres pose slow resorption rates compared to the glass and polymer microspheres.
Bone in-growth and material resorption have been improved by the development of porous calcium phosphate cements.
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