In particular, the material properties of lipid and intraplaque haemorrhage/thrombus (IPH/T) have never been explored.
However, it is not possible to determine if the additional material lost is of lipid or peptide origin.
Liposome, one of the most investigated lipid-based carriers, is a spherical vesicle composed of lipid material and has been widely used for drug delivery due to improved safety profile, high delivery efficiency, favorable pharmacokinetics, and ease of surface modification[7].
The primary mechanism of this interdependence is the sheer volume of lipid material involved.
In experiments resulting in the formation of NLP from serum, a milky type of coloration could often be seen associated with the NLP pellets and this material appeared to be of lipid origin.
In 1977, Sorensen et al. [ 11] showed loss of lipid material during SEC of liposomes.
However, if the column is not presaturated with lipids this type of chromatography causes a significant loss of lipid material.
Concentrations of the residue were notably low in tissues of the nervous system despite the high content of lipid material.
Scores for the 11 individual parameters ranged from 0 (no finding) to 4 (severe) with the parameters including necrosis, inflammation, polymorphonuclear neutrophils (PMNs), macrophages, lymphocytes, plasma cells, giant cells, fibroplasia, fibrosis, presence of lipid material and relative size.
This was indicated, however, that ex novo biosynthesis of lipid material cannot take place at the same time as the de novo process since FFAs can inhibit two key genes involved in de novo lipid accumulation: ATP-citrate lyase and fatty acid synthetases [ 88– 90].
