28, 29, 30 GPAs are those patent applications containing at least one genetic-based term, for example, nucleic acids, genetic material, mutation or genetic engineering (as specified in the supplementary data).
Several genetic and epigenetic processes contribute to the silencing of tumour suppressor genes, including loss of genetic materials, mutation, promoter methylation, histone acetylation and post-transcriptional regulation by micro RNAs, etc. Loss of heterozygosity and deletion of chromosome 5p13, where DAB2 is located, is uncommon in NPC according to our previous studies [ 29- 31].
The radiation decay products ionize genetic material, causing mutations that sometimes turn cancerous.
Influenza virus strains evolve rapidly because their genetic material accumulates mutations quickly.
There is considerable evidence that inhaled toxicants such as cigarette smoke can cause both irreversible changes to the genetic material (DNA mutations) and putatively reversible changes to the epigenetic landscape (changes in the DNA methylation and chromatin modification state).
Hoogkamp, T. & van den Ende, R. Development of amylose-free (amf) monoploid potatoes as new basic material for mutation breeding in vitro.
Tables and supplementary materials represent mutations in a different and more varied way, including splitting elements of a genome sequence change across different columns of structured file in diverse ways.
These chemical directly damage DNA, our genetic material, and initiate mutations that can lead to the development of cancer.
In addition to loss of chromosomal material and intragenic mutations there is a third mechanism, DNA methylation, which may have an important role in gene inactivation.
So far, neuronal mitochondrial studies have all used pharmacological agents to impair mitochondrial function, since fresh neuronal material possessing mtDNA mutations is not readily available.
