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(Fig. 4B, Supporting online material: Materials and Methods, Figure S1, S2).

The chimeric proteins GDAP1-Vamp1B and GDAP1-OMb5, raTMDscr TMDscr, HD1scr, HD1del, TMD+1V, TMD+3V, TMD+5V, TMD-1V and FLAG-tagged GDAP1 were generated by PCR as described in the online supplemental material (Materials and Methods S1).

See Supplementary Material, Materials and Methods for immunocytochemistry experiments.

See Supplementary Material, Materials and Methods for a description of behavioural and Echo MRI analysis.

qPCR, western blotting, dismutase activity and immunoprecipitation protocols are available in Supplementary Material, Materials and Methods.

Motor neuron culture and measurement of mitochondrial membrane potential are described in Supplementary Material, Materials and Methods.

One inhibitor 'BMPPB-32' is a new LRRK2 reference compound characterized by high specificity and selectivity to the LRRK2 kinase domain (see Supplementary Material, Material and Methods).

Further details about selection criteria, cancer diagnosis, genotyping and quality control in each study are provided in the Supplementary Material, Material and methods.

The Chinese lung cancer GWAS included 2338 lung cancer cases and 3077 controls from the Nanjing and Beijing Lung Cancer Studies (15) genotyped using Affymetrix Human SNP Array 6.0 chips (Supplementary Material, Material and methods).

Thus, mutant mice carrying Rara-, Rarg-, or Aldh1a3-null alleles were mated, and we dosed pregnant females at GD10.5 with TCDD or vehicle [see Supplemental Material, "Material and Methods" (http://dx.doi.org/10.1289/ehp.1003075)].

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